Apply When The Follicle Is Listening
Hair follicles aren't passive tissue behaving identically around the clock. They carry their own peripheral circadian clock — the same machinery that governs sleep. Applying at night also means the actives sit undisturbed for hours instead of being brushed, styled or sweated off.
Linked studyPeer-reviewed · ex vivo
Researchers at the University of Manchester found that organ-cultured human hair follicles express core clock genes and proteins — CLOCK, BMAL1 and Period1 — with genuine circadian rhythmicity, establishing that the follicle's own clock helps regulate hair cycling independently of the brain's.
Al-Nuaimi Y, Hardman JA, Bíró T, et al. "A Meeting of Two Chronobiological Systems: Circadian Proteins Period1 and BMAL1 Modulate the Human Hair Cycle Clock." Journal of Investigative Dermatology, 2014;134:610–619. Read the study →
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